RSC Advances

One-flask synthesis of 1, 3, 5-trisubstituted 1, 2, 4-triazoles from nitriles and hydrazonoyl chlorides via 1, 3-dipolar cycloaddition

…, K Kaneko, FY Cheng, HS Shih, FF Wong, JJ Huang

文献索引：Wang, Li-Ya; Tsai, Henry J.; Lin, Hui-Yi; Kaneko, Kimiyoshi; Cheng, Fen-Ying; Shih, Hsin-Siao; Wong, Fung Fuh; Huang, Jiann-Jyh RSC Advances, 2014 , vol. 4, # 27 p. 14215 - 14220

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被引用次数: 8

摘要

A one-flask strategy for the synthesis of 1, 3, 5-trisubstituted 1, 2, 4-triazoles 4a–s and 8a and b from nitriles 5a–i with N-arylhydrazonoyl hydrochlorides 3a–h and 7a and b under basic conditions was developed. The reaction provided the desired 1, 2, 4-triazoles in moderate to excellent yields (56–98%), and was applicable to aliphatic and aromatic nitriles as well as N-phenylhydrazonoyl hydrochlorides bearing ester and acetyl functionalities. A ...