Canadian Journal of Chemistry

Synthesis of 2, 2-disubstituted-6-cyanocyclohexanones

SS Kulp

文献索引：Kulp,S.S. Canadian Journal of Chemistry, 1967 , vol. 45, p. 1981 - 1986

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被引用次数: 6

摘要

The synthesis of a series of 2, 2-disubstituted-6-cyanocyclohexanones by hydrolysis of the precursor 3, 3-disubstituted-2-amino-1-cyanocyclohexenes (2, 2-disubstituted-6- cyanocyclohexanoneimines) is described. The appropriate disubstituted acetonitriles reacted with 1-chloro-4-bromobutane to give the chloro nitriles, which were converted into the 2, 2-disubstituted-heptanedinitriles for cyclization. The cyclic imino nitriles (enamines) ...