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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Folate antagonists. 22. Antimalarial and antibacterial effects of 2, 4-diamino-6-quinazolinesulfonamides

…, NL Colbry, J Davoll, MP Hutt, JL Johnson…

文献索引：Elslager; Colbry; Davoll; Hutt; Johnson; Werbel Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1740 - 1743

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被引用次数: 22

摘要

The even greater activity uncovered with the development of the 6-arylthio analogues represented by 11, demonstrating the utility of a S spacer coupled with the possibility of introducing a dual inhibitory mechanism; ie, inhibition, of PABA incorporation along with DHFR inhibition encouraged the preparation of a series of 2, 4-di-amino-6- quinazolinesulfonamides 111. The synthesis and biological activity of this series are the ...

2,4,6-triamino-5-chloroquinazoline结构式

2,4,6-triamino-...

~%

2,4-diamino-5-chloro-N,N-diethylquinazoline-6-sulfonamide结构式

2,4-diamino-5-c...

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2,4-diamino-5-chloroquinazoline-6-sulfonyl chloride结构式

2,4-diamino-5-c...

二乙胺结构式

~%

2,4-diamino-5-chloro-N,N-diethylquinazoline-6-sulfonamide结构式

2,4-diamino-5-c...

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N,N-二乙基-N'-甲基乙二胺结构式

N,N-二乙基-N'-甲基乙二胺

未登录结构式

~60%

2,4-diamino-N-[2-(diethylamino)ethyl]-N-methylquinazoline-6-sulfonamide结构式

2,4-diamino-N-[...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diamino-N-[2-(diethylamino)ethyl]-N-methylquinazoline-6-sulfonamide结构式

2,4-diamino-N-[...

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4-哌啶基哌啶结构式

4-哌啶基哌啶

未登录结构式

~45%

6-(4-piperidin-1-ylpiperidin-1-yl)sulfonylquinazoline-2,4-diamine结构式

6-(4-piperidin-...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-(4-piperidin-1-ylpiperidin-1-yl)sulfonylquinazoline-2,4-diamine结构式

6-(4-piperidin-...

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N-哌嗪甲酸乙酯结构式

N-哌嗪甲酸乙酯

未登录结构式

~55%

ethyl 4-(2,4-diaminoquinazolin-6-yl)sulfonylpiperazine-1-carboxylate结构式

ethyl 4-(2,4-di...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

ethyl 4-(2,4-diaminoquinazolin-6-yl)sulfonylpiperazine-1-carboxylate结构式

ethyl 4-(2,4-di...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide结构式

2,4-diamino-N-(...

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未登录结构式

3,4-二氯苯胺结构式

3,4-二氯苯胺

~41%

2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide结构式

2,4-diamino-N-(...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-pyrrolidin-1-ylsulfonylquinazoline-2,4-diamine结构式

6-pyrrolidin-1-...

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四氢吡咯结构式

未登录结构式

~29%

6-pyrrolidin-1-ylsulfonylquinazoline-2,4-diamine结构式

6-pyrrolidin-1-...

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3-氯-N-甲基苯胺结构式

3-氯-N-甲基苯胺

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~44%

2,4-diamino-N-(3-chlorophenyl)-N-methylquinazoline-6-sulfonamide结构式

2,4-diamino-N-(...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diamino-N-(3-chlorophenyl)-N-methylquinazoline-6-sulfonamide结构式

2,4-diamino-N-(...

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未登录结构式

N-甲基苯胺结构式

~60%

2,4-diamino-N-methyl-N-phenylquinazoline-6-sulfonamide结构式

2,4-diamino-N-m...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-piperidin-1-ylsulfonylquinazoline-2,4-diamine结构式

6-piperidin-1-y...

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六氢吡啶结构式

未登录结构式

~36%

6-piperidin-1-ylsulfonylquinazoline-2,4-diamine结构式

6-piperidin-1-y...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diamino-N-methyl-N-phenylquinazoline-6-sulfonamide结构式

2,4-diamino-N-m...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diamino-N-[(3,4-dichlorophenyl)methyl]-N-methylquinazoline-6-sulfonamide结构式

2,4-diamino-N-[...

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N-(3,4-二氯苄基)-N-甲胺结构式

N-(3,4-二氯苄基)-N-甲胺

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~36%

2,4-diamino-N-[(3,4-dichlorophenyl)methyl]-N-methylquinazoline-6-sulfonamide结构式

2,4-diamino-N-[...

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未登录结构式

~%

2,4-diaminoquinazoline-6-sulfonamide结构式

2,4-diaminoquin...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diaminoquinazoline-6-sulfonamide结构式

2,4-diaminoquin...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diamino-N-(3-bromophenyl)quinazoline-6-sulfonamide结构式

2,4-diamino-N-(...

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未登录结构式

3-溴苯胺结构式

~41%

2,4-diamino-N-(3-bromophenyl)quinazoline-6-sulfonamide结构式

2,4-diamino-N-(...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)quinazoline-2,4-diamine结构式

6-(3,4-dihydro-...

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1,2,3,4-四氢异喹啉结构式

1,2,3,4-四氢异喹啉

未登录结构式

~35%

6-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)quinazoline-2,4-diamine结构式

6-(3,4-dihydro-...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

2,4-diamino-N,N-dipropylquinazoline-6-sulfonamide结构式

2,4-diamino-N,N...

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二正丙胺结构式

未登录结构式

~%

2,4-diamino-N,N-dipropylquinazoline-6-sulfonamide结构式

2,4-diamino-N,N...

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硫代吗啉结构式

未登录结构式

~65%

6-thiomorpholin-4-ylsulfonylquinazoline-2,4-diamine结构式

6-thiomorpholin...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-thiomorpholin-4-ylsulfonylquinazoline-2,4-diamine结构式

6-thiomorpholin...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-Quinazolinesulfonamide,2,4-diamino-N,N-diethyl结构式

6-Quinazolinesu...

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未登录结构式

二乙胺结构式

~%

6-Quinazolinesulfonamide,2,4-diamino-N,N-diethyl结构式

6-Quinazolinesu...

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吗啉结构式

未登录结构式

~59%

6-morpholin-4-ylsulfonylquinazoline-2,4-diamine结构式

6-morpholin-4-y...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-morpholin-4-ylsulfonylquinazoline-2,4-diamine结构式

6-morpholin-4-y...

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2,4,6-triamino-5-chloroquinazoline结构式

2,4,6-triamino-...

~%

2,4-diamino-5-chloro-N,N-dimethylquinazoline-6-sulfonamide结构式

2,4-diamino-5-c...

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quinazoline-2,4-diamine,sulfuric acid结构式

quinazoline-2,4...

~%

6-(4-methylpiperazin-1-yl)sulfonylquinazoline-2,4-diamine结构式

6-(4-methylpipe...

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N-甲基哌嗪结构式

未登录结构式

~41%

6-(4-methylpiperazin-1-yl)sulfonylquinazoline-2,4-diamine结构式

6-(4-methylpipe...

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2,4-diamino-5-chloroquinazoline-6-sulfonyl chloride结构式

2,4-diamino-5-c...

二甲胺结构式

~%

2,4-diamino-5-chloro-N,N-dimethylquinazoline-6-sulfonamide结构式

2,4-diamino-5-c...

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