Synthetic communications

“Instant Methylide” Modification of the Corey–Chaykovsky Cyclopropanation Reaction

JA Ciaccio, CE Aman

文献索引：Ciaccio, James A.; Aman, Courtney E. Synthetic Communications, 2006 , vol. 36, # 10 p. 1333 - 1341

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被引用次数: 12

摘要

Abstract Treatment of various electron??deficient alkenes in DMSO with stable, dry, equimolar mixtures of either Me3S (O) I/KO t??Bu or Me3S (O) I/NaH cleanly afforded the corresponding substituted cyclopropanes in good yields and short reaction times (< 20 min for reactions at 50–60° C using 0.4–4.0 mmol alkene).