Medicinal Chemistry Research

Synthesis and bioactivity of some new 1-tolyl-3-aryl-4-methylimidazole-2-thiones

A Saeed, M Batool

文献索引：Saeed, Aamer; Batool, Mahira Medicinal Chemistry Research, 2007 , vol. 16, # 3 p. 143 - 154

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被引用次数: 17

摘要

Abstract Three series of new 1-(isomeric methyl) benzoyl-3-arylthioureas (1–3a–i) were prepared from 2-, 3-, and 4-methylbenzoyl chlorides via isothiocyanate formation followed by treatment with various substituted anilines. The base-catalyzed condensation of thioureas (1–3a–i) with acetone was carried out in the presence of bromine to afford the corresponding 1-(isomeric methyl) benzoyl-3-aryl-4-methyl-imidazole-2-thiones (4–6a–i) ...