Discovery of novel orally active ureido NPY Y5 receptor antagonists

…, KC Cheng, J Cook, C Farley, J Gao, L Ghibaudi…

文献索引：Li, Guoqing; Stamford, Andrew W.; Huang, Ying; Cheng, Kuo-Chi; Cook, John; Farley, Constance; Gao, Jun; Ghibaudi, Lorraine; Greenlee, William J.; Guzzi, Mario; van Heek, Margaret; Hwa, Joyce J.; Kelly, Joe; Mullins, Deborra; Parker, Eric M.; Wainhaus, Sam; Zhang, Xiaoping Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1146 - 1150

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被引用次数: 13

摘要

We have derived a novel series of neuropeptide Y (NPY) Y5 receptor antagonists from the biphenylurea 3. Cyclohexylurea 21c, a member of the series, is a potent NPY Y5 receptor antagonist that exhibits excellent pharmacokinetic parameters in rats and dogs. On ...