Aminoimidazo [1, 2-a] pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation

C Jaramillo, JE de Diego, C Hamdouchi…

文献索引：Jaramillo, Carlos; De Diego, J. Eugenio; Hamdouchi, Chafiq; Collins, Elizabeth; Keyser, Heather; Sanchez-Martinez, Concha; Del Prado, Miriam; Norman, Bryan; Brooks, Harold B.; Watkins, Scott A.; Spencer, Charles D.; Dempsey, Jack Alan; Anderson, Bryan D.; Campbell, Robert M.; Leggett, Tellie; Patel, Bharvin; Schultz, Richard M.; Espinosa, Juan; Vieth, Michal; Zhang, Faming; Timm, David E. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6095 - 6099

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被引用次数: 26

摘要

We have identified a novel structural class of protein serine/threonine kinase inhibitors comprised of an aminoimidazo [1, 2-a] pyridine nucleus. Compounds from this family are shown to potently inhibit cyclin-dependent kinases by competing with ATP for binding to a catalytic subunit of the protein. Structure-based design approach was used to direct this chemical scaffold toward generating potent and selective CDK2 inhibitors. The discovery ...