Synlett

Introduction of the acetate unit to the 2-pyridinone ring system and its application to the synthesis of (20S)-camptothecin DE ring system

K Hiroya, K Kawamoto, T Sakamoto

文献索引：Hiroya, Kou; Kawamoto, Kei; Sakamoto, Takao Synlett, 2006 , # 16 p. 2636 - 2640

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被引用次数: 4

摘要

Our synthetic strategy is shown in Figure [2] . The DE ring system (S)-6 can be synthesized from 7 by enantioselective hydroxylation of the lactone, followed by removal of the protecting group (R 1 ). The lactone 7 can be constructed from 8 by the selective reduction of the alkoxycarbonyl group. The key reaction of this synthesis is the introduction of the butyrate unit into the 3-substituted-2-pyridinone derivative 9. ... To clarify the reactivity of 3- ...