Tetrahedron: Asymmetry

Enzyme-catalysed approach to the preparation of triazole antifungals: synthesis of (−)-genaconazole

D Acetti, E Brenna, C Fuganti, FG Gatti, S Serra

文献索引：Acetti, Daniela; Brenna, Elisabetta; Fuganti, Claudio; Gatti, Francesco G.; Serra, Stefano Tetrahedron Asymmetry, 2009 , vol. 20, # 20 p. 2413 - 2420

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被引用次数: 9

摘要

The work describes a new enzyme-mediated approach to optically active epoxide (2R, 3S)- 6, which is an important key intermediate in the preparation of single enantiomers of chiral azole antifungals. The conversion of (2R, 3S)-6 into (−)-genaconazole is reported as an example of its synthetic relevance.