Bioreductive production of enantiopure (S)-duloxetine intermediates catalyzed with ketoreductase ChKRED15

ZQ Ren, Y Liu, XQ Pei, HB Wang, ZL Wu

文献索引：EP1486493 A1, ; Page 33 ;

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被引用次数: 4

摘要

... Volume 113, March 2015, Pages 76–81. ... Purified enzymes were analyzed by SDS-PAGE and used for enzymatic assays. ... Conserved residues of the SDR family, such as the active-site tetrad of NSYK [32], the structure association motif NNAG [33] and activity association motif ...