Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution

…, J Mandíková, F Trejtnar, J Kuneš, M Doležal

文献索引：Zitko, Jan; Paterova, Pavla; Kubicek, Vladimir; Mandikova, Jana; Trejtnar, Frantisek; Kunes, Jiri; Dolezal, Martin Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 2 p. 476 - 479

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被引用次数: 9

摘要

A series of 19 new compounds related to pyrazinamide were synthesized, characterized with analytical data and screened for in vitro whole cell antimycobacterial activity against Mycobacterium tuberculosis H37Rv, Mycobacterium kansasii and two types of Mycobacterium avium. The series consisted of 3-(benzylamino)-5-cyanopyrazine-2- carboxamides and 3-(benzylamino) pyrazine-2, 5-dicarbonitriles with various substituents ...