Synthesis and biological activity of 8-azapurine and pyrazolo [4, 3-d] pyrimidine analogues of myoseverin

…, P Barbier, V Peyrot, A Hlobilková, L Havlíček…

文献索引：Krystof, Vladimir; Moravcova, Daniela; Paprskarova, Martina; Barbier, Pascale; Peyrot, Vincent; Hlobilkova, Alice; Havlicek, Libor; Strnad, Miroslav European Journal of Medicinal Chemistry, 2006 , vol. 41, # 12 p. 1405 - 1411

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被引用次数: 36

摘要

The trisubstituted purine myoseverin has been recently identified as a novel inhibitor of microtubule assembly. To analyze the effects of modifying its heterocyclic skeleton, we prepared 8-azapurine and pyrazolo [4, 3-d] pyrimidine analogues of myoseverin and compared their biological activities. Rearrangement of nitrogen atoms in the heterocycle changes the affinity of the compounds to purified tubulin, as demonstrated by the results of ...