Tetrahedron letters

A new and simple 'LEGO'system for the synthesis of branched oligopyridines

GR Pabst, K Schmid, J Sauer

文献索引：Pabst, Gunther R.; Schmid, Konrad; Sauer, Juergen Tetrahedron Letters, 1998 , vol. 39, # 37 p. 6691 - 6694

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被引用次数: 41

摘要

The condensation of carboxamidrazones 1 with 1, 2-dicarbonyl compounds 2 is the best method for the synthesis of alkyl, aryl or hetaryl substituted 1, 2, 4-triazines 3–7. These 1, 2, 4-triazines can be easily transformed to pyridines 8–12 by [4+ 2] cycloaddition with bicyclo [2.2. 1] hepta-2, 5-diene followed by [4+ 2] cycloreversions of nitrogen and cyclopentadiene. This reaction sequence offers a new, simple and general access to branched ...