The Journal of Organic Chemistry

1, 4-Dichloro-1, 4-dimethoxybutane as a mild reagent for the conversion of primary amines to pyrroles. Synthesis of a pyrrole compound from tobacco

TH Chan, SD Lee

文献索引：Chan, T. H.; Lee, S. D. Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 3059 - 3061

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被引用次数: 28

摘要

The conversion of primary amines to pyrroles has previously been achieved by reaction with 2, 5-dimethoxytetrahydrofuran (1) under refluxing acetic acid.'The reaction is useful for the synthesis of a number of N-substituted pyrroles. It is obviously not applicable to compounds that are acid or heat sensitive.