Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF …

…, F Colbatzky, S Handschuh, J Kley…

文献索引：Varma, Rajendra S.; Verma, Kaushal K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 877 - 879

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被引用次数: 110

摘要

... Journal of Medicinal ... KG, A-1121 Vienna, Austria. J. Med. ... HCl, K 2 CO 3 , NaI, acetone, 50 °C; (e) MeI, KOtBu, DMSO, rt; (f) N,N,N′-trimethylpropane-1,3-diamine, NEt 3 , CH 2 Cl 2 , 0 °C, then 79 or 80, rt; (g) chloroacetyl chloride, NEt 3 , THF, rt; (h) dimethylamine·HCl, K 2 CO 3 ...