Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis

Y Iwata, M Arisawa, R Hamada, Y Kita…

文献索引：Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728

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被引用次数: 63

摘要

Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Due to the limited number of currently available drugs for the treatment of diabetic complications, we have carried out structure-based drug design and synthesis in an attempt to find new types of AR inhibitors. With the ADAM&EVE program, a three-dimensional database (ACD3D) was searched using the ligand binding site of the AR crystal structure. Out of 179 ...