The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones

…, DJ Cowan, RW Wiethe, ID Correa…

文献索引：Willson, Timothy M.; Cobb, Jeffery E.; Cowan, David J.; Wiethe, Robert W.; Correa, Itzela D.; et al. J. Med. Chem., 1996 , vol. 39, # 3 p. 665 - 668

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被引用次数: 745

摘要

Results. A series of compounds (1b− 11) was chosen from the literature that had been previously tested in rodent models of diabetes. 4, 7, 9-11 Clofibric acid (1b), the active form of clofibrate (1a), 15 was purchased from Sigma. Compounds 2− 11 were synthesized by the literature methods. 7, 9-11 The compounds were tested in a transient transfection assay in CV-1 cells for their ability to activate PPARs. To allow comparison of the relative ...