Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogs
…, JC Sircar, MK Dong, RB Gilbertsen
文献索引：Woo, Peter W. K.; Kostlan, Catherine R.; Sircar, Jagadish C.; Dong, Mi K.; Gilbertsen, Richard B. Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1451 - 1457
A seriea of% substituted hypoxanthines (610, 14-17) and related analogues (22, s) have been syntheaized as inhibitors of purine nucleoside phosphorylase (PNP), which may conceivably act as T-cell-selective immunosuppressive agents with potential utility in autoimmune disorders such as rheumatoid arthritis, in organ transplantations, and in T-cell leukemias. The compounds were evaluated for their PNP activity by a radiochemical ...
