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Microwave-assisted synthesis of thieno [2, 3-c] pyridine derivatives as a new series of allosteric enhancers at the adenosine A 1 receptor

R Romagnoli, PG Baraldi, AR Moorman…

文献索引:Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533

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被引用次数: 15

摘要

The microwave-assisted aromatization method has been used for the synthesis of a series of novel thieno [2, 3-c] pyridines. This rapid method produces compounds in good yield within minutes in comparison with conventional heating method. The synthesized molecules have been evaluated as a potential new series of allosteric enhancers acting at the adenosine A1 receptor. In a functional assay, one compound (3h) showed activity comparable with that ...

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