Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis

…, R Stroud, PR Ortiz de Montellano

文献索引：He, Xin; Alian, Akram; Stroud, Robert; Ortiz De Montellano, Paul R. Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6308 - 6323

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被引用次数: 135

摘要

In view of the worldwide spread of multidrug resistance of Mycobacterium tuberculosis, there is an urgent need to discover antituberculosis agent with novel structures. InhA, the enoyl acyl carrier protein reductase (ENR) from M. tuberculosis, is one of the key enzymes involved in the mycobacterial fatty acid elongation cycle and has been validated as an effective antimicrobial target. We report here the discovery, through high-throughput ...