Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes

…, R Atsumi, M Minami, M Mochizuki, K Hirotani…

文献索引：Naito, Hiroyuki; Ohsuki, Satoru; Atsumi, Ryo; Minami, Megumi; Mochizuki, Mineko; Hirotani, Kenji; Kumazawa, Eiji; Ejima, Akio Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 153 - 163

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被引用次数: 18

摘要

A series of novel 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans- propenes and related compounds were synthesized and evaluated by their cytotoxic activity against several tumor cell lines in vitro and in vivo antitumor activity against some tumor models when administered both intraperitoneally and orally. Compounds with the 3- chloropyridin-2-yl group (9g) and the 3-fluoro-5-substituted phenylpiperazinyl group (29b, ...