2-Pyridon-1-yl diphenyl phosphate is found to be a useful coupling agent for the synthesis of amides and practically race m iza tion -fr ee pe pt id es . ... Among a large number of coupling agents for peptide synthesis,' phosphorus-based coupling agents have attracted a great deal of recent attention.2 In the course of our work in developing new effective coupling agents,3 we have found that 2-pyridon-1-yl diphenyl phosphate is easily prepared by simply mixing ...