Abstract The synthesis of tritium labelled thiomuscimol (5-amino [3 H] 2 methyl-3- isothiazolol)(7c), a specific and high-affinity agonist photoaffinity label for GABA A receptors, is described. The synthesis of 7c is based on a procedure for the preparation of 5-amino [2 H] 2 methyl-3-isothiazolol (7b). Methyl 3-ethoxyisothiazole-5-carboxylate (3), synthesized from 3-hydroxyisothiazole-5-carboxamide (1) via the corresponding methyl ester (2), was ...
