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Organic letters

Continuous Synthesis and Use of N-Heterocyclic Carbene Copper (I) Complexes from Insoluble Cu2O

…, JK Park, AR Longstreet, DT McQuade

文献索引:Opalka, Suzanne M.; Park, Jin Kyoon; Longstreet, Ashley R.; McQuade, D. Tyler Organic Letters, 2013 , vol. 15, # 5 p. 996 - 999

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被引用次数: 30

摘要

It is demonstrated that homogeneous N-heterocyclic carbene–copper (I)-chloride complexes can be prepared continuously by flowing NHC precursors through a packed bed of solid Cu2O suspended in molecular sieves. The method enables the synthesis of a wide range of complexes including those that are challenging to prepare using standard approaches. Our strategy enables both sustained output of complex production for long-term catalytic ...