Journal of heterocyclic chemistry

Reaction of 5??(3, 4??dimethoxyphenyl) pyrazine??2, 3??dicarbonitrile with alcohol in the presence of base

K Tsuzuki, M Tada

文献索引：Tsuzuki, Koichi; Tada, Masaru Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1365 - 1368

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被引用次数: 3

摘要

Abstract 5-(3, 4-Dimethoxyphenyl) pyrazine-2, 3-dicarbonitrile reacts with methanol to give addition products, 3-methoxyiminopyrazine-2-carbonitrile and 2-methoxyiminopyrazine-3- carbonitrile derivatives, and/or substitution products, 3-methoxypyrazine-2-carbonitrile and 2- methoxypyrazine-3-carbonitrile derivatives. The selectivity between the addition and substitution depends on solvent polarity, base, and reaction time. The experimental results ...