Multicomponent Cascade Reactions: A Novel and Expedient Approach to Functionalized Indoles by an Unprecedented Nucleophilic Addition??Heterocyclization?? …

…, G Salerno, R Mancuso, M Costa

文献索引：Gabriele, Bartolo; Mancuso, Raffaella; Salerno, Giuseppe; Costa, Mirco Advanced Synthesis and Catalysis, 2006 , vol. 348, # 9 p. 1101 - 1109

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被引用次数: 34

摘要

Abstract A novel multicomponent cascade process is reported, based on the sequential combination between an initial nucleophilic attack step to an imine moiety and a palladium- catalyzed oxidative heterocyclization-alkoxycarbonylation process. By this new process, five simple molecules [2-alkynylaniline imines, alcohol (ROH), carbon monoxide (CO), alcohol (ROH), and oxygen (O 2)] are sequentially activated, selectively leading to high value- ...