Tetrahedron letters

A novel approach to tricyclic pharmaceuticals via directed dilithiation of diaryl compounds

VB Birman, A Chopra, CA Ogle

文献索引：Birman, Vladimir B.; Chopra, Anu; Ogle, Craig A. Tetrahedron Letters, 1996 , vol. 37, # 29 p. 5073 - 5076

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被引用次数: 13

摘要

Tricyclic compounds were prepared using a novel approach based on the reaction between dilithio-diphenyl ether with appropriately substituted esters. The pharmaceutical drug, clopipazan, and its corresponding deschloro analog were synthesized utilizing this approach.