Tetrahedron

Isotopically sensitive branching as a tool for evaluating multiple product formation by monoterpene cyclases

K Wagschal, TJ Savage, R Croteau

文献索引：Wagschal, Kurt; Savage, Thomas J.; Croteau, Rodney Tetrahedron, 1991 , vol. 47, # 31 p. 5933 - 5944

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被引用次数: 57

摘要

The deuterated substrates [4-2H2, 1-3H] geranyl pyrophosphate and [10-2H3, 1-3H] geranyl pyrophosphate were employed to examine isotopically sensitive branching in the biosynthesis of monoterpene olefin isomers. By this method,(−)-α-pinene and (−)-β-pinene were shown to be synthesized via a common intermediate by a single cyclization enzyme from grand fir (Abies grandis), as were (−)-(α-phellandrene and (−)-β-phellandrene by a ...