Carboxamido derivatives of the tetracyclines

WJ Gottstein, WF Minor, LC Cheney

文献索引：Gottstein et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 1198,1200

全文：HTML全文

被引用次数: 39

摘要

N-(Morpholinomethq. 1)-tetracycline (VI) has been prepared in a high yield by the interaction of tetracycline (I), morpholine and formaldehyde in t-butyl alcohol. Treatment of VI with an aqueous solution of sodium bisulfite and also lowpressure hydrogenolpsis of VI with Raney nickel catalyst have regenerated tetracycline. Other substantial evidence that the rnorpholinomethyl radical is attached to the nitrogen atom of the carboxamido grouping ...