(1 R, 2 R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1, 3, 4, 5-tetrahydropyrido [4, 3-b] indole-2-carbonyl) cyclohexanecarboxamide (AZD4996): A Potent and Highly …

AG Dossetter, H Beeley, J Bowyer…

文献索引：Journal of Medicinal Chemistry, , vol. 55, # 14 p. 6363 - 6374

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被引用次数: 16

摘要

... Journal of Medicinal Chemistry. ... but is not always successful in alleviating pain and restoring function.(5) Articular cartilage breakdown is a prominent feature of joint degeneration and has consequently received significant attention from the pharmaceutical industry, where ...