Abstract A series of phthalimido phosphor derivatives—α-amino-phosphonates, amidophosphonates, phosphonic acid diamides, and oxadiazaphospholes—were prepared by applying different types of phosphorus (III) reagents to 2-methoxy-1 H-isoindole-1, 3 (2 H)- dione and 2-anilino-1 H-isoindole-1, 3 (2 H)-dione. On the basis of bioassay results, some of the new phosphoryl imides could be considered as lead molecules to be modified in order ...