Nucleosides & nucleotides

Tetraethylene glycol-derived spacer for oligonucleotide synthesis

S Gunzenhauser, E Biala…

文献索引：Gunzenhauser; Biala; Strazewski Nucleosides and Nucleotides, 1999 , vol. 18, # 6-7 p. 1223 - 1224

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被引用次数: 2

摘要

Abstract 3, 6, 9-Trioxaundecane-1, 11-diisocyanate (6) was synthesised from tetraethylene glycol in 5 steps and 48% overall yield. Spacer 6 was monofunctionalised with the fully protected adenosyl-3′-O-succinate derivative 7 and linked to aminomethyl polystyrene