Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo [2, 1-b] thiadiazole and imidazo [2, 1-b] thiazolesulfonamides

IT Barnish, PE Cross, RP Dickinson…

文献索引：Barnish; Cross; Dickinson; Gadsby; Parry; Randall; Sinclair Journal of medicinal chemistry, 1980 , vol. 23, # 2 p. 117 - 121

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被引用次数: 48

摘要

Because of the increase in the number of elderly people, cerebrovascular disease is now becoming a major medical and social problem; there is, therefore, an urgent need to discover an effective therapy that will improve the function of the aging brain. It is known that the degree and extent of the neurological deficit correlate with decreases in both cerebral blood flow and oxygen~ tilization,'-~ but it is not known whether either of these constitutes ...