Heterocyclic analogs of prostaglandines: IV. Synthesis of 3, 7-interphenylene 3, 10 (11)-dioxa-13-azaprostanoids and 9-oxa-7-azaprostanoids based on tetronic acid …

FS Pashkovskii, EM Shchukina, MG Gribovskii…

文献索引：Pashkovskii; Shchukina; Gribovskii; Lakhvich Russian Journal of Organic Chemistry, 2008 , vol. 44, # 5 p. 657 - 670

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被引用次数: 14

摘要

Abstract An approach was developed to the synthesis of stable in metabolism 3, 7- interphenylene 3, 10-dioxa-13-aza-and 3, 11-dioxa-13-azaprostanoids, and also 9-oxa-7- azaprostanoids with interphenylene and terminal phenyl fragments in the ω-chain based on 3-(alkoxybenzylidene)-and 3-(3-phenylallylidene) tetrahydrofuran-2, 4-diones obtained by Knoevenagel condensation of tetronic acid with alkoxy-substituted aromatic aldehydes ...