Syntheses of 9-acridine-and 2-phenanthridinemethanols as potential antimalarials

CW Muth, HL Minigh, S Chookruvong…

文献索引：Muth; Minigh; Chookruvong; Hall; Chao Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 1016 - 1018

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被引用次数: 5

摘要

5 thesis and for antimalarial testing. Compound 3 is like 1 except that 3 lacks the benzo group and the chlorines of 1. Compound 4 is a chain homologue of 2 and 3. The dihydrochloride of 3 is ineffective against P. berghei in mice and P. berghei in vitro (infra). We have been unable to synthesize 4. We did make the 9, lO-dihydro derivative of 4 which has negligible activity against P. berghei in mice. We have also made 5 which is ...