New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure activity relationships and pharmacological …
Fourteen new CPP analogues have been prepared with methyl 1-(phenylmethyl)(= k)-1, 2- piperazinedicarboxylate 3 as a versatile synthetic intermediate. Derivatives were evaluated as NMDA ligands by their ability to displace [3H] CPP from rat cortical membranes. The binding affinity of various chain lengths at the N4-position of the CPP analogues, 5a, 5b, and 9a mimica the binding affinity observed for the acyclic derivatives AP6, AP8, and AP5. ...
