Tetrahedron letters

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

…, DD Wisnoski, SE Wolkenberg, WH Leister, Y Wang…

文献索引：Zhao, Zhijian; Wisnoski, David D.; Wolkenberg, Scott E.; Leister, William H.; Wang, Yi; Lindsley, Craig W. Tetrahedron Letters, 2004 , vol. 45, # 25 p. 4873 - 4876

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被引用次数: 244

摘要

Functionalized quinoxalines and heterocyclic pyrazines are expediently prepared in excellent yields (69–99%) from common 1, 2-diketone intermediates under microwave irradiation. In addition to being general for a variety of aryl/heteroaryl 1, 2-diamines and 1, 2- diketones, this protocol suppresses the formation of polymeric species, characteristic of traditional thermal conditions.