European journal of medicinal chemistry

Augmentation of GABAergic neurotransmission by novel N-(substituted)-2-[4-(substituted) benzylidene] hydrazinecarbothioamides—A potential anticonvulsant …

L Tripathi, P Kumar

文献索引：Tripathi, Laxmi; Kumar, Praveen European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 477 - 487

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被引用次数: 4

摘要

New N-(substituted)-2-[4-(substituted) benzylidene] hydrazinecarbothioamides were designed, synthesized and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity was established in three seizure models ie MES, scMET and 6 Hz model. The most active compound was N-(4-methoxyphenyl)-2-[4-(4-methylphenoxy) benzylidene] hydrazinecarbothioamide PT 30 which showed 100% protection in both ...