Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H 3 receptor antagonists

NC Becknell, JA Lyons, LD Aimone, JA Gruner…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 23 p. 7076 - 7080

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被引用次数: 12

摘要

... Bioorganic & Medicinal Chemistry Letters. ... One strategy, which is the focus of this Letter, was to synthesize and evaluate the pyridone replacements for the pyridazinone and evaluate the H 3 R binding SAR, pharmacokinetics (PK), selectivity and drug-like properties for a series ...