Discovery of 4, 5-Diphenyl-1, 2, 4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human V 1A Receptor

…, T Tobe, A Tahara, S Sakamoto, S Tsukamoto

文献索引：Kakefuda, Akio; Suzuki, Takeshi; Tobe, Takahiko; Tahara, Atsuo; Sakamoto, Shuichi; Tsukamoto, Shin ichi Bioorganic and medicinal chemistry, 2002 , vol. 10, # 6 p. 1905 - 1912

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被引用次数: 32

摘要

In the search for a novel class of selective antagonists for the human V1A receptor, high- throughput screening (HTS) of the Yamanouchi chemical library using CHO cells expressing the cloned human V1A (hV1A) receptor led to the discovery of 5-(4-biphenyl)-4-(2- methoxyphenyl)-3-methyl-1, 2, 4-triazole (3) which possessed the novel 4, 5-diphenyl-1, 2, 4- triazole structure. Subsequent structure–activity relationships studies on a series of the 4, ...