Oxadiazoles have often been described as bio-isosteres for amides and esters [1, 2, 3]. Due to increased hydrolytic [4] and metabolic stability of the oxadiazole ring, improved pharmacoknetic and in-vivo performance is often observed, which make these heterocycles an important structural motif for the pharmaceutical industry. As a consequence of these characteristics, oxadiazoles have impacted numerous drug discovery programs including ...
