Domino Cyclization of 2??Isothiocyanatobenzonitrile with Carboxylic Hydrazides− One??Pot Synthesis of 1, 2, 4??Triazolo [1, 5??c] quinazoline??5 (6H)??thiones

…, WD Pfeiffer, A Hetzheim, P Langer

文献索引：Blank, Janet; Kandt, Madeleine; Pfeiffer, Wolf-Diethard; Hetzheim, Annemarie; Langer, Peter European Journal of Organic Chemistry, 2003 , # 1 p. 182 - 189

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被引用次数: 20

摘要

Abstract One-pot reactions between carboxylic hydrazides and 2-isothiocyanatobenzonitrile afforded pharmacologically relevant 1, 2, 4-triazolo [1, 5-c] quinazoline-5 (6H)-thiones in good yields. These compounds were transformed into the corresponding amino-substituted derivatives in good yields in one or two steps.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)