Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14α-demethylase (CYP51) of fungi

J Zhu, J Lu, Y Zhou, Y Li, J Cheng, C Zheng

文献索引：Zhu, Ju; Lu, Jiaguo; Zhou, Youjun; Li, Yaowu; Cheng, Jun; Zheng, Canhui Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5285 - 5289

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被引用次数: 42

摘要

Novel tetrahydroisoquinoline compounds were designed by coupling structure-based de novo design based on the structure of lanosterol 14α-demethylase (CYP51). The chemical synthesis and the antifungal activities in vitro of them were reported. The results exhibited ...