Synthesis and antitumour effect of the melanogenesis-based antimelanoma agent N-propionyl-4-S-cysteaminylphenol

M Tandon, PD Thomas, M Shokravi, S Singh…

文献索引：Tandon, Manju; Thomas, Panakkezhum D.; Shokravi, Mohammed; Singh, Shradha; Samra, Satinder; Chang, Daniel; Jimbow, Kowichi Biochemical Pharmacology, 1998 , vol. 55, # 12 p. 2023 - 2029

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被引用次数: 30

摘要

Chemotherapy of malignant melanoma is still a great challenge, as no effective drugs are available. The development of melanogenesis-based drugs is a promising area of research because melanogenesis is a unique biochemical pathway operating only in melanoma cells (and their normal counterparts) so that the tumour can be targeted. We have been using cysteinylphenol, a sulphur-containing analogue of tyrosine, and derivatives for that ...