Tetrahedron letters

Rhodium-hydroxyl bisphospholane catalyzed highly enantioselective hydrogenation of dehydroamino acids and esters

W Li, Z Zhang, D Xiao, X Zhang

文献索引：Li, Wenge; Zhang, Zhaoguo; Xiao, Dengming; Zhang, Xumu Tetrahedron Letters, 1999 , vol. 40, # 37 p. 6701 - 6704

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被引用次数: 60

摘要

A chiral hydroxyl bisphospholane, 1, 2-bis [(2S, 3S, 4S, 5S)-3, 4-dihydroxyl-2, 5- dimethylphospholanyl] benzene (4), was synthesized from readily available d-mannitol. Its Rh (I) complex catalyzes asymmetric hydrogenation of dehydroamino acids and their ester derivatives with excellent enantioselectivities (98 to> 99% ee).