A NEW SYNTHESIS OF FLUMAZENEL SUITABLE FOR FLUORINE-18 LABELING

G Broggini, M Orlandi, A Turconi…

文献索引：Broggini, Gianluigi; Orlandi, Marco; Turconi, Alberto; Zoni, Caterina Organic Preparations and Procedures International, 2003 , vol. 35, # 6 p. 609 - 613

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被引用次数: 9

摘要

In recent years, fluorinated organic compounds have assumed an increasing importance in the biomedical area owing to the concomitance of various factors such as (i) the great stability of the carbon-fluorine bond, particularly in terms of thermal and oxidative degradation (ii) the similar steric requirements of the fluorine and hydrogen atoms which allows similar metabolic pathways and (iii) the enhanced lipophilicity which leads to ...