Synthesis and structure-activity studies of novel orally active non-terpenoic 2, 3-oxidosqualene cyclase inhibitors

…, EM von der Mark, J Himber, OH Morand

文献索引：Dehmlow, Henrietta; Aebi, Johannes D.; Jolidon, Synese; Ji, Yu-Hua; Von der Mark, Elisabeth M.; Himber, Jacques; Morand, Olivier H. Journal of Medicinal Chemistry, 2003 , vol. 46, # 15 p. 3354 - 3370

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被引用次数: 56

摘要

New orally active non-terpenoic inhibitors of human 2, 3-oxidosqualene cyclase (hOSC) are reported. The starting point for the optimization process was a set of compounds derived from a fungicide project, which in addition to showing high affinity for OSC from Candida albicans showed also high affinity for human OSC. Common structural elements of these inhibitors are an amine residue and an electrophilic carbonyl C atom embedded in a ...