Synthesis and structure-activity relations of disodium cromoglycate and some related compounds

H Cairns, C Fitzmaurice, D Hunter…

文献索引：Cairns,H. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, # 6 p. 583 - 589

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被引用次数: 66

摘要

3-[ 5-(4-Acetamidophenyl)-2-tet1azolyl]propionic Acid (14). A solution of 5 g (0.022 mole) of 3-(5-(4-aminophenyl)-2-tetrazolyl]- propionic acid 34 in 200 ml of Ac,O was allowed to stand for 24 hr at room temperature. The reaction was diluted with 2 1. of water and the solid collected and dried. Recrystallization from MeOH gave 2.4 g (40%) of fine white needles, mp 218”. 3-[5-(4-Phenylazophenyl)-2-tetrazolyl]propionic Acid (16). A solution of 10 g (0.043 mole) ...