Tetrahedron

Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship

C Girlanda-Junges, F Keyling-Bilger, G Schmitt, B Luu

文献索引：Girlanda-Junges, Celine; Keyling-Bilger, Florence; Schmitt, Gaby; Luu, Bang Tetrahedron, 1998 , vol. 54, # 27 p. 7735 - 7748

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被引用次数: 34

摘要

Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω- alkanol side chain were synthesized using “Umpolung” reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω- hydroxy side chain is a crucial factor for biological activity.