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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of previously inaccessible quinazolines and 1, 4-benzodiazepines as potential anticonvulsants

…, NA Vaidya, WB Iturrian, CDW Blanton Jr

文献索引：Fatmi, Aqeel A.; Vaidya, Niteen A.; Iturrian, W. B.; Blanton, C. DeWitt Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 772 - 778

全文：HTML全文

被引用次数: 11

摘要

A series of 4, 6, 7, 8-tetrasubstituted 3, 4-dihydroquinazolines, quinazolines, quinazolin-2- ones, 1, 2, 3; 4-tetrahydroquinazolin-2-ones, and 5, 7, 8, 9-tetrasubstituted 1, Cbenzodiazepines have been synthesized by utilizing the Diels-Alder reaction between furan o-amino nitriles and various alkyl or aryl vinyl ketone dienophiles to obtain the anthranilic acid precursors. All of the newly synthesized target compounds were evaluated ...

1-cyclohexyl-2-propen-1-one结构式

1-cyclohexyl-2-...

~%

2-amino-3-(cyclohexanecarbonyl)-5,6-dimethylbenzonitrile结构式

2-amino-3-(cycl...

6-amino-5-benzoyl-3-hydroxy-2,3-dimethylcyclohexa-1,5-diene-1-carbonitrile结构式

6-amino-5-benzo...

~91%

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

6-amino-5-benzoyl-3-hydroxy-2,3-dimethylcyclohexa-1,5-diene-1-carbonitrile结构式

6-amino-5-benzo...

~59%

3-benzoyl-2-hydroxy-5,6-dimethylbenzonitrile结构式

3-benzoyl-2-hyd...

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

苯基丙烯基酮结构式

苯基丙烯基酮

~%

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

3-acetyl-2-amino-5,6-dimethylbenzonitrile结构式

3-acetyl-2-amin...

三氯乙酰氯结构式

三氯乙酰氯

~99%

N-(6-acetyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-acetyl-2-c...

5-acetyl-6-amino-3-hydroxy-2,3-dimethyl-cyclohexa-1,5-diene-1-carbonitrile结构式

5-acetyl-6-amin...

~%

N-(6-acetyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-acetyl-2-c...

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

三氯乙酰氯结构式

三氯乙酰氯

~88%

N-(6-benzoyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-benzoyl-2-...

苯基丙烯基酮结构式

苯基丙烯基酮

~%

N-(6-benzoyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-benzoyl-2-...

6-amino-5-benzoyl-3-hydroxy-2,3-dimethylcyclohexa-1,5-diene-1-carbonitrile结构式

6-amino-5-benzo...

~%

N-(6-benzoyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-benzoyl-2-...

N-(6-acetyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-acetyl-2-c...

~76%

4,6,7-trimethyl-2-oxo-3H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

5-acetyl-6-amino-3-hydroxy-2,3-dimethyl-cyclohexa-1,5-diene-1-carbonitrile结构式

5-acetyl-6-amin...

~%

4,6,7-trimethyl-2-oxo-3H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

3-acetyl-2-amino-5,6-dimethylbenzonitrile结构式

3-acetyl-2-amin...

~%

4,6,7-trimethyl-2-oxo-3H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

2,2,2-trichloro-N-(2-cyano-6-(cyclohexanecarbonyl)-3,4-dimethylphenyl)acetamide结构式

2,2,2-trichloro...

~80%

4-cyclohexyl-6,7-dimethyl-2-oxo-3H-quinazoline-8-carbonitrile结构式

4-cyclohexyl-6,...

1-cyclohexyl-2-propen-1-one结构式

1-cyclohexyl-2-...

~%

4-cyclohexyl-6,7-dimethyl-2-oxo-3H-quinazoline-8-carbonitrile结构式

4-cyclohexyl-6,...

2-amino-3-(cyclohexanecarbonyl)-5,6-dimethylbenzonitrile结构式

2-amino-3-(cycl...

~%

4-cyclohexyl-6,7-dimethyl-2-oxo-3H-quinazoline-8-carbonitrile结构式

4-cyclohexyl-6,...

1-(2-fluorophenyl)prop-2-en-1-one结构式

1-(2-fluorophen...

~%

2-amino-3-(2-fluorobenzoyl)-5,6-dimethylbenzonitrile结构式

2-amino-3-(2-fl...

1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one结构式

1-[2-(trifluoro...

~%

2-amino-5,6-dimethyl-3-[2-(trifluoromethyl)benzoyl]benzonitrile结构式

2-amino-5,6-dim...

1-(2-chlorophenyl)prop-2-en-1-one结构式

1-(2-chlorophen...

~%

2-amino-3-(2-chlorobenzoyl)-5,6-dimethylbenzonitrile结构式

2-amino-3-(2-ch...

N-(6-benzoyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-benzoyl-2-...

~87%

6,7-dimethyl-2-oxo-4-phenyl-1H-quinazoline-8-carbonitrile结构式

6,7-dimethyl-2-...

6-amino-5-benzoyl-3-hydroxy-2,3-dimethylcyclohexa-1,5-diene-1-carbonitrile结构式

6-amino-5-benzo...

~%

6,7-dimethyl-2-oxo-4-phenyl-1H-quinazoline-8-carbonitrile结构式

6,7-dimethyl-2-...

苯基丙烯基酮结构式

苯基丙烯基酮

~%

6,7-dimethyl-2-oxo-4-phenyl-1H-quinazoline-8-carbonitrile结构式

6,7-dimethyl-2-...

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

~%

6,7-dimethyl-2-oxo-4-phenyl-1H-quinazoline-8-carbonitrile结构式

6,7-dimethyl-2-...

3-acetyl-2-amino-5,6-dimethylbenzonitrile结构式

3-acetyl-2-amin...

溴乙酰溴结构式

~86%

N-(6-acetyl-2-cyano-3,4-dimethylphenyl)-2-bromoacetamide结构式

N-(6-acetyl-2-c...

5-acetyl-6-amino-3-hydroxy-2,3-dimethyl-cyclohexa-1,5-diene-1-carbonitrile结构式

5-acetyl-6-amin...

~%

N-(6-acetyl-2-cyano-3,4-dimethylphenyl)-2-bromoacetamide结构式

N-(6-acetyl-2-c...

1-(4-甲氧基苯基)丙-2-烯-1-酮结构式

1-(4-甲氧基苯基)丙-2-烯-1-酮

~%

2-amino-3-(4-methoxybenzoyl)-5,6-dimethylbenzonitrile结构式

2-amino-3-(4-me...

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

溴乙酰溴结构式

~93%

N-(6-benzoyl-2-cyano-3,4-dimethylphenyl)-2-bromoacetamide结构式

N-(6-benzoyl-2-...

6-amino-5-benzoyl-3-hydroxy-2,3-dimethylcyclohexa-1,5-diene-1-carbonitrile结构式

6-amino-5-benzo...

~%

N-(6-benzoyl-2-cyano-3,4-dimethylphenyl)-2-bromoacetamide结构式

N-(6-benzoyl-2-...

苯基丙烯基酮结构式

苯基丙烯基酮

~%

N-(6-benzoyl-2-cyano-3,4-dimethylphenyl)-2-bromoacetamide结构式

N-(6-benzoyl-2-...

6-amino-5-benzoyl-3-hydroxy-2,3-dimethylcyclohexa-1,5-diene-1-carbonitrile结构式

6-amino-5-benzo...

~25%

3-benzoyl-2-hydroxy-5,6-dimethylbenzonitrile结构式

3-benzoyl-2-hyd...

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

苯基丙烯基酮结构式

苯基丙烯基酮

~%

3-benzoyl-2-hydroxy-5,6-dimethylbenzonitrile结构式

3-benzoyl-2-hyd...

2-氨基-4,5-二甲基-3-呋喃甲腈结构式

2-氨基-4,5-二甲基-3-呋喃甲腈

丁烯酮结构式

~84%

3-acetyl-2-hydroxy-5,6-dimethylbenzonitrile结构式

3-acetyl-2-hydr...

甲亚胺酸结构式

2-amino-3-(cyclohexanecarbonyl)-5,6-dimethylbenzonitrile结构式

2-amino-3-(cycl...

~91%

4-cyclohexyl-6,7-dimethyl-1,4-dihydroquinazoline-8-carbonitrile结构式

4-cyclohexyl-6,...

1-cyclohexyl-2-propen-1-one结构式

1-cyclohexyl-2-...

~%

4-cyclohexyl-6,7-dimethyl-1,4-dihydroquinazoline-8-carbonitrile结构式

4-cyclohexyl-6,...

甲亚胺酸结构式

未登录结构式

~36%

4-methyl-6,7-diphenyl-1,4-dihydroquinazoline-8-carbonitrile结构式

4-methyl-6,7-di...

4,6,7-trimethyl-2-oxo-3H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

~69%

4,6,7-trimethyl-2-oxo-3,4-dihydro-1H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

5-acetyl-6-amino-3-hydroxy-2,3-dimethyl-cyclohexa-1,5-diene-1-carbonitrile结构式

5-acetyl-6-amin...

~%

4,6,7-trimethyl-2-oxo-3,4-dihydro-1H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

3-acetyl-2-amino-5,6-dimethylbenzonitrile结构式

3-acetyl-2-amin...

~%

4,6,7-trimethyl-2-oxo-3,4-dihydro-1H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

N-(6-acetyl-2-cyano-3,4-dimethylphenyl)-2,2,2-trichloroacetamide结构式

N-(6-acetyl-2-c...

~%

4,6,7-trimethyl-2-oxo-3,4-dihydro-1H-quinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

3-acetyl-2-amino-5,6-dimethylbenzonitrile结构式

3-acetyl-2-amin...

甲亚胺酸结构式

~73%

4,6,7-trimethylquinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

5-acetyl-6-amino-3-hydroxy-2,3-dimethyl-cyclohexa-1,5-diene-1-carbonitrile结构式

5-acetyl-6-amin...

~%

4,6,7-trimethylquinazoline-8-carbonitrile结构式

4,6,7-trimethyl...

甲亚胺酸结构式

2-amino-3-benzoyl-5,6-dimethylbenzonitrile结构式

2-amino-3-benzo...

~71%

6,7-dimethyl-4-phenylquinazoline-8-carbonitrile结构式

6,7-dimethyl-4-...

苯基丙烯基酮结构式

苯基丙烯基酮

~%

6,7-dimethyl-4-phenylquinazoline-8-carbonitrile结构式

6,7-dimethyl-4-...

6-amino-5-benzoyl-3-hydroxy-2,3-dimethylcyclohexa-1,5-diene-1-carbonitrile结构式

6-amino-5-benzo...

~%

6,7-dimethyl-4-phenylquinazoline-8-carbonitrile结构式

6,7-dimethyl-4-...

5-acetyl-6-amino-3-hydroxy-2,3-dimethyl-cyclohexa-1,5-diene-1-carbonitrile结构式

5-acetyl-6-amin...

~%

8-Quinazolinecarbonitrile,1,4-dihydro-4,6,7-trimethyl-结构式

8-Quinazolineca...

甲亚胺酸结构式

2-amino-3-(2-fluorobenzoyl)-5,6-dimethylbenzonitrile结构式

2-amino-3-(2-fl...

~80%

4-(2-fluorophenyl)-6,7-dimethylquinazoline-8-carbonitrile结构式

4-(2-fluorophen...

1-(2-fluorophenyl)prop-2-en-1-one结构式

1-(2-fluorophen...

~%

4-(2-fluorophenyl)-6,7-dimethylquinazoline-8-carbonitrile结构式

4-(2-fluorophen...